{"ret":200,"data":{"code":0,"msg":"circRNA query success","data":{"Info":{"circRNA":"hsa_circ_0001946","Species":"Homo sapiens","Position":"chrX:139865339-139866824","Expression":"Up;Down;Up;Up;Down;Up;Up;Up;Down;Up","Method":"Microarray\/qRT-PCR","Detection":"NA","Gene":"CDR1","Gene_link":"https:\/\/www.ncbi.nlm.nih.gov\/gene\/1038","Gene_description":"cerebellar degeneration related protein 1","Tissue":"Pancreatic ductal adenocarcinoma;Glioblastoma multiforme;Colorectal cancer;Hepatocellular Carcinoma;Alzheimer's disease brain tissues;Esophageal squamous cell carcinoma;Periodontal ligament stem cell;Laryngeal squamous cell carcinoma;Bladder cancer;Non-small cell lung cancer","Gene_omim_link":"https:\/\/omim.org\/entry\/302650","Function":"hsa_circ_0001946 promotes growth and metastasis of esophageal squamous cell carcinoma via regulation of miR-7\/HOXB13; hsa_circ_0001946 regulates osteoblastic differentiation of periodontal ligament stem cells via the miR-7\/GDF5\/SMAD and p38 MAPK signaling pathway. hsa_circ_0001946 is an oncogene that promotes LSCC progression by regulating miR-7 signals; hsa_circ_0001946 exerts anti-oncogenic functions in bladder cancer by sponging microRNA-135a; hsa_circ_0001946 functions as an oncogene to promote the tumor progression via miR-7 in non-small cell lung cancer; regulation of CDR1 mRNA level; miR-7 sponge; regulation of insulin transcription and secretion in islet cells; Alzheimer's disease; myocardial infarction; hsa_circ_0001946 (ciRS-7, Cdr1as) acts as an oncogene partly through targeting miR-7 in Hepatocellular carcinoma; hsa_circ_0001946 accelerates ESCC progression through acting as a miR-876-5p sponge to enhance MAGE-A family expression; hsa_circ_0001946 is a biomarker for hepatic microvascular invasion; overexpression of ciRS-7 abrogates the tumor suppressive effect of miR-7 on gastric cancer via PTEN\/PI3K\/AKT signaling pathway; ciRS-7 promotes APP and BACE1 degradation in an NF-kB-dependent manner; inhibition of miR-7 and subsequent activation of EGFR and RAF1 oncogenes; the axis miR-671-5p\/CDR1-AS\/CDR1\/VSNL1 is functionally altered in glioblastoma multiforme cells and is involved in the modification of their biopathological profile; hsa_circ_0001946 may serve as a potential vicious molecular biomarker to predict the aggressive tumor progression and worse prognosis for Cholangiocarcinoma patients; pancreatic ductal adenocarcinoma [differential expression (pancreatic ductal adenocarcinoma vs. matched adjacent normal samples)]","PMID":"21964070;23446348;23446346;26211738;27929395;27391479;27614453;28608528;28296235;28174233;26683098;27997903;28892615;29424892;29635069;30082829;30170617;30182381;29694981;30207835;30022841","circRNA_link":"http:\/\/www.circbase.org\/cgi-bin\/singlerecord.cgi?id=hsa_circ_0001946"},"Interaction":{"RBP":["AGO1","AGO2","FUS","IGF2BP1","IGF2BP2","IGF2BP3","TDP43","TNRC6"],"miRNA":["hsa-miR-1270","hsa-miR-3156-5p","hsa-miR-576-3p","hsa-miR-671-5p","hsa-miR-6807-5p","hsa-miR-7-5p","hsa-miR-8056"]}}},"msg":""}