Detail

General Information

CircRNA hsa_circ_0067934 Species Homo sapiens
Location chr3:170013698-170015181 OMIM ID 600539
Method Microarray/qRT-PCR Detection Tool -
Gene Symbol PRKCI Gene Description protein kinase C iota
Function Proliferation and migration of esophageal squamous cell carcinoma cells; hsa_circ_0067934 represents a novel potential biomarker and therapeutic target of esophageal squamous cell carcinoma. hsa_circ_0067934 functions as a sponge for both miR-545 and miR-589 and abrogates their suppression of the pro-tumorigenic transcription factor E2F7. hsa_circ_0067934 promotes tumor growth in lung adenocarcinoma; down-regulation of hsa_circ_0067934 inhibits cell migration and proliferation in Hirschsprung disease by suppressing the expression of miR-1324 target PLCB1.

Expression profiles of hsa_circ_0067934

Tissue Hirschsprung disease aganglionic tissuesEsophageal squamous cell carcinomaLung adenocarcinoma
Expression DownUpUp

RNA-binding Protein(s) Matching to hsa_circ_0067934

GO Annotations of PRKCI

GO:0006468protein phosphorylationbiological process
GO:0006612protein targeting to membranebiological process
GO:0007010cytoskeleton organizationbiological process
GO:0007015actin filament organizationbiological process
GO:0010976positive regulation of neuron projection developmentbiological process
GO:0016192vesicle-mediated transportbiological process
GO:0016477cell migrationbiological process
GO:0018105peptidyl-serine phosphorylationbiological process
GO:0032869cellular response to insulin stimulusbiological process
GO:0034351negative regulation of glial cell apoptotic processbiological process
GO:0035089establishment of apical/basal cell polaritybiological process
GO:0035556intracellular signal transductionbiological process
GO:0042462eye photoreceptor cell developmentbiological process
GO:0043066negative regulation of apoptotic processbiological process
GO:0043524negative regulation of neuron apoptotic processbiological process
GO:0045197establishment or maintenance of epithelial cell apical/basal polaritybiological process
GO:0045216cell-cell junction organizationbiological process
GO:0046326positive regulation of glucose importbiological process
GO:0046903secretionbiological process
GO:0048194Golgi vesicle buddingbiological process
GO:0051092positive regulation of NF-kappaB transcription factor activitybiological process
GO:0060252positive regulation of glial cell proliferationbiological process
GO:0061024membrane organizationbiological process
GO:0070555response to interleukin-1biological process
GO:0070830bicellular tight junction assemblybiological process
GO:1903078positive regulation of protein localization to plasma membranebiological process
GO:2000353positive regulation of endothelial cell apoptotic processbiological process
GO:0000139Golgi membranecellular component
GO:0005634nucleuscellular component
GO:0005768endosomecellular component
GO:0005829cytosolcellular component
GO:0005886plasma membranecellular component
GO:0005923bicellular tight junctioncellular component
GO:0015630microtubule cytoskeletoncellular component
GO:0016324apical plasma membranecellular component
GO:0031252cell leading edgecellular component
GO:0043220Schmidt-Lanterman incisurecellular component
GO:0043234protein complexcellular component
GO:0045171intercellular bridgecellular component
GO:0070062extracellular exosomecellular component
GO:0004672protein kinase activitymolecular function
GO:0004674protein serine/threonine kinase activitymolecular function
GO:0004697protein kinase C activitymolecular function
GO:0005515protein bindingmolecular function
GO:0005524ATP bindingmolecular function
GO:0005543phospholipid bindingmolecular function
GO:0019904protein domain specific bindingmolecular function
GO:0046872metal ion bindingmolecular function

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>hsa_circ_0067934|ENST00000295797
GTTATTTTGGAAAAACAAATTCGCATACCACGTTCTCTGTCTGTAAAAGCTGCAAGTGTTCTGAAGAGTTTTCTTAATAAGGACCCTAAGGAACGATTGGGTTGTCATCCTCAAACAGGATTTGCTGATATTCAGGGACACCCGTTCTTCCGAAATGTTGATTGGGATATG

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