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Hierarchical Browser
- pathways
- pathways[8]
- Signaling by Notch (pathway 1)
- Transport of Notch receptor precursor to golgi (pathway 2)
- Maturation of Notch precursor via proteolytic cleavage (pathway 3)
- Mature Notch receptor trafficks to plasma membrane (pathway 4)
- Notch receptor binds with a ligand (pathway 5)
- Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor (pathway 6)
- A third proteolytic cleavage releases NICD (pathway 7)
- NICD trafficks to nucleus (pathway 8)
- pathway components[35]
- pathway component 1
- pathway component 2
- pathway component 3
- pathway component 4
- pathway component 5
- pathway component 6
- pathway component 7
- pathway component 8
- pathway component 9
- pathway component 10
- pathway component 11
- pathway component 12
- pathway component 13
- pathway component 14
- pathway component 15
- pathway component 16
- pathway component 17
- pathway component 18
- pathway component 19
- pathway component 20
- pathway component 21
- pathway component 22
- pathway component 23
- pathway component 24
- pathway component 25
- pathway component 26
- pathway component 27
- pathway component 28
- pathway component 29
- pathway component 30
- pathway component 31
- pathway component 32
- pathway component 33
- pathway component 34
- pathway component 35
- pathways[8]
- Reactants
- complex[19]
- NTM-NEC 1 heterodimer [Golgi lumen] (complex 1)
- NTM-NEC 2 heterodimer [Golgi lumen] (complex 2)
- NTM-NEC 3 heterodimer [Golgi lumen] (complex 3)
- NTM-NEC 4 heterodimer [Golgi lumen] (complex 4)
- NTM-NEC 1 heterodimer [plasma membrane] (complex 5)
- NTM-NEC 2 heterodimer [plasma membrane] (complex 6)
- NTM-NEC 3 heterodimer [plasma membrane] (complex 7)
- NTM-NEC 4 heterodimer [plasma membrane] (complex 8)
- NTM-NEC1-Notch ligand complex [extracellular region] (complex 9)
- NTM-NEC2-Notch ligand complex [extracellular region] (complex 10)
- NTM-NEC3-Notch ligand complex [extracellular region] (complex 11)
- NTM-NEC4-Notch ligand complex [extracellular region] (complex 12)
- Notch 1 ligand-bound fragment-Notch ligand complex [plasma membrane] (complex 13)
- ADAM 10 metalloprotease (Zn cofactor) [plasma membrane] (complex 14)
- Notch 2 ligand-bound fragment-Notch ligand complex [plasma membrane] (complex 15)
- Notch 3 ligand-bound fragment-Notch ligand complex [plasma membrane] (complex 16)
- Notch 4 ligand-bound fragment-Notch ligand complex [plasma membrane] (complex 17)
- gamma-secretase complex [plasma membrane] (complex 18)
- Presenilin homodimer [plasma membrane] (complex 19)
- protein[10]
- UniProt:P46531 NOTCH1 (protein 1)
- UniProt:Q04721 NOTCH2 (protein 2)
- UniProt:Q9UM47 NOTCH3 (protein 3)
- UniProt:Q99466 NOTCH4 (protein 4)
- UniProt:P09958 FURIN (protein 5)
- Notch Ligand [plasma membrane] (protein 6)
- UniProt:O14672 ADAM10 (protein 7)
- UniProt:Q9NZ42 PSENEN (protein 8)
- Presenilin [plasma membrane] (protein 9)
- Nicastrin [plasma membrane] (protein 10)
- smallMolecule[1]
- others[1]
- complex[19]
- Interactions
- biochemicalReaction[28]
- Notch 1 precursor transport to golgi (biochemicalReaction 1)
- Notch 2 precursor transport to golgi (biochemicalReaction 2)
- Notch 3 precursor transport to golgi (biochemicalReaction 3)
- Notch 4 precursor transport to golgi (biochemicalReaction 4)
- Notch 1 precursor cleaved to form a heterodimer (biochemicalReaction 5)
- Notch 2 precursor cleaved to form a heterodimer (biochemicalReaction 6)
- Notch 3 precursor cleaved to form a heterodimer (biochemicalReaction 7)
- Notch 4 precursor cleaved to form a heterodimer (biochemicalReaction 8)
- Notch 1 heterodimer trafficks to the plasma membrane (biochemicalReaction 9)
- Notch 2 heterodimer trafficks to the plasma membrane (biochemicalReaction 10)
- Notch 3 heterodimer trafficks to the plasma membrane (biochemicalReaction 11)
- Notch 4 heterodimer trafficks to the plasma membrane (biochemicalReaction 12)
- Notch 1 heterodimer binds with a Notch ligand in the extracellular space (biochemicalReaction 13)
- Notch 2 heterodimer binds with a Notch ligand in the extracellular space (biochemicalReaction 14)
- Notch 3 heterodimer binds with a Notch ligand in the extracellular space (biochemicalReaction 15)
- Notch 4 heterodimer binds with a Notch ligand in the extracellular space (biochemicalReaction 16)
- Notch 1-ligand complex is cleaved to produce NEXT1 (biochemicalReaction 17)
- Notch 2-ligand complex is cleaved to produce NEXT2 (biochemicalReaction 18)
- Notch 3-ligand complex is cleaved to produce NEXT3 (biochemicalReaction 19)
- Notch 4-ligand complex is cleaved to produce NEXT4 (biochemicalReaction 20)
- NEXT1 is cleaved to produce NICD1 (biochemicalReaction 21)
- NEXT2 is cleaved to produce NICD2 (biochemicalReaction 22)
- NEXT3 is cleaved to produce NICD3 (biochemicalReaction 23)
- NEXT4 is cleaved to produce NICD4 (biochemicalReaction 24)
- NICD1 trafficks to the nucleus (biochemicalReaction 25)
- NICD2 trafficks to the nucleus (biochemicalReaction 26)
- NICD3 trafficks to the nucleus (biochemicalReaction 27)
- NICD4 trafficks to the nucleus (biochemicalReaction 28)
- catalysis[12]
- #serine_type_endopeptidase_activity_of_furin__Golgi_membrane_ (catalysis 1)
- #serine_type_endopeptidase_activity_of_furin__Golgi_membrane_1 (catalysis 2)
- #serine_type_endopeptidase_activity_of_furin__Golgi_membrane_2 (catalysis 3)
- #serine_type_endopeptidase_activity_of_furin__Golgi_membrane_3 (catalysis 4)
- #metallopeptidase_activity_of_ADAM_10_metalloprotease__Zn_cofactor___plasma_membrane_ (catalysis 5)
- #metallopeptidase_activity_of_ADAM_10_metalloprotease__Zn_cofactor___plasma_membrane_1 (catalysis 6)
- #metallopeptidase_activity_of_ADAM_10_metalloprotease__Zn_cofactor___plasma_membrane_2 (catalysis 7)
- #metallopeptidase_activity_of_ADAM_10_metalloprotease__Zn_cofactor___plasma_membrane_3 (catalysis 8)
- #aspartic_type_endopeptidase_activity_of_gamma_secretase_complex__plasma_membrane_ (catalysis 9)
- #aspartic_type_endopeptidase_activity_of_gamma_secretase_complex__plasma_membrane_1 (catalysis 10)
- #aspartic_type_endopeptidase_activity_of_gamma_secretase_complex__plasma_membrane_2 (catalysis 11)
- #aspartic_type_endopeptidase_activity_of_gamma_secretase_complex__plasma_membrane_3 (catalysis 12)
- biochemicalReaction[28]
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