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Hierarchical Browser
- Sasagawa2005_MAPK
- Reactants[99]
- EGFR (#EGFR)
- L_EGFR (#L_EGFR)
- L_EGFR_dimer (#L_EGFR_dimer)
- SOS (#SOS)
- L_dpEGFR (#L_dpEGFR)
- pSOS (#pSOS)
- SOS_Grb2 (#SOS_Grb2)
- Grb2 (#Grb2)
- Dok (#Dok)
- pDok (#pDok)
- Crk (#Crk)
- FRS2 (#FRS2)
- Shc (#Shc)
- pSOS_Grb2 (#pSOS_Grb2)
- Rap1_GDP (#Rap1_GDP)
- MEK (#MEK)
- MKP3 (#MKP3)
- pShc_dpEGFR (#pShc_dpEGFR)
- dpEGFR_c_Cbl (#dpEGFR_c_Cbl)
- B_Raf_Rap1_GTP (#B_Raf_Rap1_GTP)
- pShc_dpEGFR_c_Cbl (#pShc_dpEGFR_c_Cbl)
- pFRS2_dpEGFR_c_Cbl (#pFRS2_dpEGFR_c_Cbl)
- Shc_dpEGFR (#Shc_dpEGFR)
- c_Cbl (#c_Cbl)
- RasGAP (#RasGAP)
- c_Raf (#c_Raf)
- B_Raf (#B_Raf)
- ERK (#ERK)
- PP2A (#PP2A)
- Ras_GDP (#Ras_GDP)
- Rap1GAP (#Rap1GAP)
- C3G (#C3G)
- NGFR (#NGFR)
- pShc (#pShc)
- pFRS2_dpEGFR (#pFRS2_dpEGFR)
- pTrkA_endo (#pTrkA_endo)
- MEK_ERK (#MEK_ERK)
- pMEK_ERK (#pMEK_ERK)
- FRS2_dpEGFR_c_Cbl_ubiq (#FRS2_dpEGFR_c_Cbl_ubiq)
- Crk_C3G_pFRS2_dpEGFR_c_Cbl (#Crk_C3G_pFRS2_dpEGFR_c_Cbl)
- pShc_dpEGFR_c_Cbl_ubiq (#pShc_dpEGFR_c_Cbl_ubiq)
- Crk_C3G_pFRS2_dpEGFR (#Crk_C3G_pFRS2_dpEGFR)
- Grb2_SOS_pShc_dpEGFR_c_Cbl_ubiq (#Grb2_SOS_pShc_dpEGFR_c_Cbl_ubiq)
- Grb2_SOS_pShc_dpEGFR_c_Cbl (#Grb2_SOS_pShc_dpEGFR_c_Cbl)
- Shc_dpEGFR_c_Cbl_ubiq (#Shc_dpEGFR_c_Cbl_ubiq)
- dpEGFR_c_Cbl_ubiq (#dpEGFR_c_Cbl_ubiq)
- proteasome (#proteosome)
- Grb2_SOS_pShc (#Grb2_SOS_pShc)
- Shc_dpEGFR_c_Cbl (#Shc_dpEGFR_c_Cbl)
- Grb2_SOS_pShc_dpEGFR (#Grb2_SOS_pShc_dpEGFR)
- pFRS2 (#pFRS2)
- FRS2_dpEGFR (#FRS2_dpEGFR)
- pDok_RasGAP (#pDok_RasGAP)
- pMEK (#pMEK)
- FRS2_dpEGFR_c_Cbl (#FRS2_dpEGFR_c_Cbl)
- pFRS2_dpEGFR_c_Cbl_ubiq (#pFRS2_dpEGFR_c_Cbl_ubiq)
- Ras_GTP (#Ras_GTP)
- Crk_C3G_pFRS2_dpEGFR_c_Cbl_ubiq (#Crk_C3G_pFRS2_dpEGFR_c_Cbl_ubiq)
- c_Raf_Ras_GTP (#c_Raf_Ras_GTP)
- B_Raf_Ras_GTP (#B_Raf_Ras_GTP)
- ppMEK (#ppMEK)
- ppERK (#ppERK)
- pTrkA (#pTrkA)
- Crk_C3G (#Crk_C3G)
- Rap1_GTP (#Rap1_GTP)
- L_NGFR (#L_NGFR)
- ppMEK_ERK (#ppMEK_ERK)
- dppERK (#dppERK)
- Shc_pTrkA (#Shc_pTrkA)
- Shc_pTrkA_endo (#Shc_pTrkA_endo)
- pShc_pTrkA (#pShc_pTrkA)
- pFRS2_pTrkA (#pFRS2_pTrkA)
- FRS2_pTrkA (#FRS2_pTrkA)
- pShc_pTrkA_endo (#pShc_pTrkA_endo)
- FRS2_pTrkA_endo (#FRS2_pTrkA_endo)
- pFRS2_pTrkA_endo (#pFRS2_pTrkA_endo)
- Crk_C3G_pFRS2_pTrkA_endo (#Crk_C3G_pFRS2_pTrkA_endo)
- Grb2_SOS_pShc_pTrkA (#Grb2_SOS_pShc_pTrkA)
- Crk_C3G_pFRS2_pTrkA (#Crk_C3G_pFRS2_pTrkA)
- Grb2_SOS_pShc_pTrkA_endo (#Grb2_SOS_pShc_pTrkA_endo)
- c_Raf_Ras_GTP_MEK (#c_Raf_Ras_GTP_MEK)
- c_Raf_Ras_GTP_pMEK (#c_Raf_Ras_GTP_pMEK)
- c_Raf_Ras_GTP_MEK_ERK (#c_Raf_Ras_GTP_MEK_ERK)
- c_Raf_Ras_GTP_pMEK_ERK (#c_Raf_Ras_GTP_pMEK_ERK)
- B_Raf_Ras_GTP_MEK (#B_Raf_Ras_GTP_MEK)
- B_Raf_Ras_GTP_pMEK (#B_Raf_Ras_GTP_pMEK)
- B_Raf_Ras_GTP_MEK_ERK (#B_Raf_Ras_GTP_MEK_ERK)
- B_Raf_Ras_GTP_pMEK_ERK (#B_Raf_Ras_GTP_pMEK_ERK)
- B_Raf_Rap1_GTP_MEK (#B_Raf_Rap1_GTP_MEK)
- B_Raf_Rap1_GTP_pMEK (#B_Raf_Rap1_GTP_pMEK)
- B_Raf_Rap1_GTP_MEK_ERK (#B_Raf_Rap1_GTP_MEK_ERK)
- B_Raf_Rap1_GTP_pMEK_ERK (#B_Raf_Rap1_GTP_pMEK_ERK)
- ppERK_MKP3 (#ppERK_MKP3)
- dppERK_MKP3 (#dppERK_MKP3)
- pro_TrkA (#pro_TrkA)
- NGF (#NGF)
- EGF (#EGF)
- pro_EGFR (#pro_EGFR)
- degradation (#degradation)
- Interactions[150]
- form_EGFreceptor
- EGFbinding
- dimerization
- binding_SOS_Grb2
- binding_pSOS_Grb2
- EGFRphosphorylation
- binding_cCbI_dpEGFR
- binding_pShc_LdpEGFR
- pDOKdephosphorylation
- binding_cCbl_pShc_dpEGFR
- SOSdephosphorylation
- pSOS_Grb2_dephosphorylation
- binding_Shc_LdpEGFR
- Shc_dpEGFR_phosphorylation
- dpEGFR_c_Cbl_ubiquitination
- dpEGFR_cCbl_degrad
- binding_cCbl_Shc_dpEGFR
- Shc_dpEGFR_c_CBl_Ubiquitination
- Shc_dpEGFR_c_Cbl_ubiq_Degradation
- pShc_dpEGFR_c_Cbl_ubiquitination
- pShc_dpEGFR_c_Cbl_ubiq_degradation
- Shc_dpEGFR_c_Cblphosphorylation
- binding_Grb2_SOS_pShc
- binding_Grb2_SOS_pShc_dpEGFR
- binding_Grb2_SOS_pShc_dpEGFR
- binding_c_Cbl_Grb2_SOS_pShc_dpEGFR
- binding_Grb2_SOS_pShc_to_dpEGFR_c_Cbl
- Grb2_SOS_pShc_dpEGFR_c_Cbl_ubiquitination
- Grb2_SOS_pShc_dpEGFR_c_Cbl_ubiq_degradation
- Grb2_SOS_pShc_Dissociation
- J31
- pShc_dephosphorylation
- pFRS2_dephosphorylation
- binding_Crk_to_C3G
- binding_L_dpEGFR_to_FRS2
- binding_pFRS2_to_L_dpEGFR
- FRS2_dpEGFRphsphorylation
- binding_Crk_C3G_to_pFRS2_pRTK
- binding_c_Cbl_to_FRS2_dpEGFR
- binding_c_Cbl_to_pFRS2_dpEGFR
- pFRS2_dpEGFR_c_Cbl_ubiquitiation
- FRS2_dpEGFR_c_Cbl_ubiquitination
- FRS2_dpEGFR_c_Cbl_phosphorylation
- binding_Crk_C3G_to_pFRS2_pFRS2_dpEGFR_c_Cbl
- Crk_C3G_pFRS2_dpEGFR_c_Cbl_ubiquitination
- FRS2_dpEGFR_c_Cbl_ubiq_dissociation
- pFRS2_dpEGFR_c_Cbl_ubiq_dissociation
- binding_RasGAP_to_pDOK
- SOS_Grb2_phosphorylation
- SOS_phosphorylation
- binding_c_Raf_to_Ras_GTP
- binding_B_Raf_to_Rap1_GTP
- binding_B_Raf_to_Ras_GTP
- ppMEK_dephosphorylation
- pMEK_dephosphorylation
- ppMEK_ERK
- pMEK_ERK_dephosphorylation
- ppERK_dimerization
- Ras_GTP_dephosphorylation
- Rap1_GTP_dephosphorylation
- Rap1_GTP_phosphorylation
- Ras_GDP_phosphorylation
- binding_NGF_to_NGFR
- TrkA_phosphorylation
- pTrkA_intermalization
- pTrkA_endo_degradation
- pTrkA_degradation
- binding_Shc_to_pTrkA
- binding_pShc_to_pTrkA
- binding_FRS2_to_pTrkA
- binding_pFRS2_to_pTrkA
- binding_Shc_to_pTrkA_endo
- binding_pShc_to_pTrkA_endo
- Shc_pTrkA_endo_phosphorylation
- Shc_pTrkA_phosphorylation
- pFRS2_pTrkA_phosphorylation
- binding_FRS2_to_pTrkA_endo
- binding_pFRS2_to_pTrkA_endo
- FRS2_pTrkA_endo_phosphorylation
- FRS2_pTrkA_degradation
- pFRS2_pTrkA_degradation
- Shc_pTrkA_degradation
- pShc_pTrkA_degradation
- FRS2_pTrkA_endo_degradation
- Shc_pTrkA_endo_degradation
- pShc_pTrkA_endo_degradation
- binding_Grb2_SOS_to_pShc_pTrkA_endo
- binding_Grb2_SOS_to_pShc_pTrkA
- Grb2_SOS_pShc_pTrkA_ubiquitination
- Crk_C3G_pFRS2_pTrkA_ubiquitination
- pFRS2_pTrkA_ubiquitination
- FRS2_pTrkA_ubiquitination
- pShc_pTrkA_ubiquitination
- Shc_pTrkA_ubiquitination
- binding_Crk_C3G_to_pFRS2_pTrkA
- binding_Crk_C3G_to_pFRS2_pTrkA_endo
- binding_Grb2_SOS_pShc_to_pTrkA
- binding_Grb2_SOS_pShc_to_pTrkA_endo
- Crk_C3G_pFRS2_pTrkA_degradation
- Crk_C3G_pFRS2_pTrkA_endo_degradation
- Grb2_SOS_pShc_pTrkA_degradation
- Grb2_SOS_pShc_pTrkA_endo_degradation
- pFRS2_pTrkA_endo_degradation
- form_NGFreceptor
- binding_Shc_to_dpEGFR_c_Cbl
- binding_pShc_to_dpEGFR_c_Cbl
- binding_SOS_Grb2_to_pShc_dpEGFR_c_Cbl
- binding_c_Cbl_to_Crk_C3G_pFRS2_dpEGFR
- binding_FRS2_to_dpEGFR_c_Cbl
- binding_pFRS2_to_dpEGFR_c_Cbl
- Ras_GTP_dephosphorylation
- RAP1_GTP_dephosphorylation
- Dok_phosphorylation
- Grb1_SOS_pShc_dissociation
- binding_MEK_to_ERK
- binding_ERK_to_pMEK
- binding_ERK_to_ppMEK
- ppMEK_ERK_dissociation
- c_Raf_Ras_GTP_dissociation
- B_Raf_Ras_GTP_dissociation
- B_Raf_Rap1_GTP_dissociation
- J140
- J141
- J142
- J143
- J144
- J145
- J146
- J147
- J148
- J149
- J150
- J151
- J152
- J153
- J154
- J155
- J156
- J157
- J158
- J159
- J160
- J161
- J162
- J163
- J164
- J165
- J166
- J167
- J168
- Reactants[99]
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