Peptide Resources

Norine has been the unique resource dedicated to nonribosomal peptides (NRPs) since its first release in 2008, currently containing over 1,160 annotated peptides. It integrates structural and functional data of microbial secondary metabolites, supporting database querying by peptide annotation information or structural features. Equipped with dedicated tools for compound structure comparison and biological activity prediction, it provides systematic data support for the discovery of novel nonribosomal peptides and microbial metabolism research.

PAAP is a web server for predicting the antihypertensive activity of peptides, constructed using a random forest classifier with combinations of amino acid, dipeptide, and pseudoamino acid composition descriptors, achieving 84.73% accuracy in independent testing.

pAVP_PSSMDWT-EnC is an intelligent computational model for antiviral peptide (AVPs) identification, fusing position-specific scoring matrix (PSSM) with discrete wavelet transform (DWT) and k-segmentation to construct novel evolutionary feature descriptors.

PepBank is a comprehensive peptide sequence database containing 19,792 entries, sourced from MEDLINE abstract text mining, ASPD/UniProt public resources, and manual literature curation. It features Google-like simple search, advanced text retrieval, and BLAST/Smith-Waterman alignment capabilities, supporting affinity ligand discovery, peptide binding partner prediction, and therapeutic/diagnostic peptide development.

PepBDB is a curated structural database of peptide–protein interactions, extracting and cleaning complex structures from the Protein Data Bank (PDB). It provides extensive interaction information, supports multi-dimensional searches and interactive visualization, offering high-quality data for structure-based drug design (e.g., docking and scoring studies).