General Information
Protein IDLOC_Os12g26060        View Network
NamesPutative bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS) [Includes: Dihydrofolate reductase ; Thymidylate synthase ]
FunctionBifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Can play two different roles depending on the source of dihydrofolate: de novo synthesis of tetrahydrofolate or recycling of the dihydrofolate released as one of the end products of the TS catalyzed reaction. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP (By similarity).
AttributesLength: 470
Status: Complete
Existence: Inferred from homology
Molecular Weight: 53201.4
pI: 7.9734
Subcellular Location (adjusted): Cytosol  
Gene ModelLOC_Os12g26060.1  
Protein-Protein Interaction ( Show in Viewer )
LOC_Os04g16771   
Database Links
UniprotKBQ2QRX6
EMBLDP000011  
KEGGosa:9271078  dosa:Os12t0446900-01