RiceNetDB is currently the most comprehensive regulatory database on Oryza Sativa based on genome annotation. It was displayed in three levels: GEM, PPIs and GRNs to facilitate biomolecular regulatory analysis and gene-metabolite mapping.
| General Information | |
|---|---|
| Protein ID | LOC_Os05g46270 View Network |
| Names | Flap endonuclease 1-A (FEN-1-A) (Flap structure-specific endonuclease 1-A) (OsFEN-1a) |
| Function | Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA (By similarity). May be required for cell proliferation. |
| Attributes | Length: 340 Status: Complete Existence: Evidence at transcript level Molecular Weight: 38393.2 pI: 5.408 Subcellular Location (adjusted): Nucleus |
| Gene Model | LOC_Os05g46270.1 |
| Enzyme | 3.-.-.- Hydrolases 3.1.-.- Hydrolases acting on ester bonds |
| Database Links | |
|---|---|
| UniprotKB | Q9SXQ6 |
| Refseq | NP_001056179.1 |
| EMBL | AB021666 AC119291 AP008211 CM000142 |
| KEGG | osa:4339464 dosa:Os05t0540100-01 |